Developmental Biology: A Very Short Introduction (Very Short Introductions) by Wolpert Lewis

Author:Wolpert, Lewis [Wolpert, Lewis]
Language: eng
Format: mobi, epub
Publisher: Oxford University Press
Published: 2011-08-24T16:00:00+00:00

How reversible is cell differentiation? To what extent can the pattern of gene activity in differentiated cells revert to that found in the fertilized egg? One way of finding out whether it can be reversed is to place the nucleus of a differentiated cell in a different cytoplasmic environment, one that contains a different set of gene-regulatory proteins. This experiment led to cloning. The most dramatic experiments addressing the reversibility of differentiation have investigated the ability of nuclei from cells at different stages of development to replace the nucleus of an egg and to support normal development. If they can do this, it would indicate that no irreversible changes have occurred to the genome during differentiation. It would also show that a particular pattern of nuclear gene activity is determined by whatever transcription factors and other regulatory proteins are being synthesized in the cytoplasm of the cell.

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